Venezia started with real intention, but it was Giacomo Raspadori, who almost surprised the believers at home with a thunderous left -wing strike rattling the inside of the left post before bouncing back into the game.
Moments later, Scott McTominay Ionut tested Radu with two powerful head-piece headers, which forced the Venezia-shot stopper in a few excellent rescues while Napoli continued in an attempt to keep the same lead with competition leaders Inter Milan.
The Lagunari, however, had their best chances at the other end just before the break, when Kike Perez closed on a cross in the box and pointed a low effort to the right corner, only for Alex Meret to make a comfortable stop.
Seconds later, Amir Rrahmani was present to erase Daniel Fila's shot of the goal line after a chaotic rebound in the penalty area.
Despite the pressure, Napoli almost took the lead at the end through the header of Romelu Lukaku, who saved radically masterfully on the goal line to end an exciting first period.
The men of Antonio Conte have raised the pace after the break and delivered control over the game, but the advanced advanced in the last third could not find.
The current 11-game Windless Run van Venezia began with a narrow 1-0 loss for Napoli in the reverse fixture of December, and as the game progressed, the hosts seemed increasingly vulnerable for the first time.
Eusebio di Francesco's decision to introduce two pairs of fresh legs with 20 minutes to inject new energy into the attack of Venezia, to disturb the defense of Napoli and shift the momentum.
In the end, neither of them found an elusive winner, who has played a first draw in Series B since December 2003.
Napoli has another blow in their aim to reclaim the Scudetto, so that both Atalanta and Inter Milan are the upper hand after a seventh draw this season.
In the meantime, Venezia continues to keep five points on drift of safety, with their return to the Italian second layer that looks more and more likely as the rounds pass.
Flash score Man of the match: Ionut Radu (Venezia)
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