Inter opened the door to Napoli in the Serie A-title race after the title defender was beaten 1-0 with 1-0 on Sunday.
After he was bent from the Coppa Italia on Wednesday after a semi-final defeat in the second leg to Rivals AC Milan, Inter suffered a third loss in just seven days.
They will now focus their attention on their semi-final first stage of the Champions League in Barcelona, ​​but the Simone Inzaghi team will look nervously over their shoulders.
The hosts started clearly in the game and thought they had continued when David Fratteni found the back of the net, but his strike was excluded from offside.
Visiting goalkeeper Mile Svilar was then present to thwart Hakan Calhanoglu before Manu Kone shot Roma's first attempt at the goal of Inter.
And it was Roma who first struck in the 22nd minute when Lorenzo Pellegrini's shot bent in the path of Matias Soule, before he stroked the ball past Yann Sommer.
The Claudio Ranieri team almost doubled their advantage shortly thereafter, but Bryan Cristante could only shoot wide after he had been selected by Pellegrini's cross in the box.
Inter insisted on an equalizer after the break, but a cutting edge was missing in the last third part when Calhanoglu and Nicolo Barella widely shot from the goal.
Roma, however, threatened to increase their benefit from one goal, but the first strike by Niccolo Pissili was closely wide before Artem Dovbyk forced a rescue from Sommer.
The visitors were able to hold the victory to move them to eighth in the rankings and are now only two points on drift of the top four.
In the meantime, Inter remains a point free of Napoli, who has a match in hand, who will meet Torino later on Sunday.
Fischio Final
Driven by @Betsonsport #Forzainter #interroma pic.twitter.com/tlsbd1xsep
– Inter (@inter) April 27, 2025
Data Debrief: Roma Roll on Under Ranieri
Inter has lost three games in a row without scoring a goal in all competitions for the first time since five in a row in February 2012 (between Serie A and the Champions League), under now Roma Boss Ranieri.
It was also the first time that they had lost three games in a row in all matches, for the last time under Luciano Spalletti in December 2017.
In the meantime, Roma claimed their eighth 1-0 win in the Serie A this season, more than any other team in Europe's top five competitions this season.
They are now unbeaten in 18 consecutive games in a single Serie A season (W13, D5) for the first time since November 2009 and April 2010, when they have managed 24 with Ranieri at the helm.