The former Sporting Director of Liverpool and Tottenham moves to Juve after a spell as President of Toulouse. Comolli resigned from TFC in May.
“I am very happy and privileged to become a member of a club that is distinguished by its history, identity and ambitious vision,” Comolli said in a statement published on the Juventus website.
“From the very first day I will devote my experience to Juventus with the ultimate goal of gaining the victory – just as Juventus is intended, and as our fans are rightly expecting.”
Juve Chief Exec Maurizio Scanavino added: “We are delighted to welcome Damien and extend our best wishes for his journey with us. His expertise and professionalism will play a crucial role in the path of Juventus to constant strength and growth.”