England Women will be without injured trio Lauren James, Ella Toone and Lauren Hemp at Wembley on November 30 when they take on Emma Hayes' American side.
Manchester City announced on Tuesday that Hemp has undergone knee surgery, while Toone and James are both suffering from calf problems.
Chelsea's Niamh Charles and Aston Villa defender Lucy Parker are also sidelined.
Sarina Wiegman has therefore handed Manchester City's Laura Blindkilde Brown and Leicester City's Ruby Mace, both 21, their first senior international call-ups.
Meanwhile, Manchester United defender Gabby George, who suffered an ACL injury last year, has returned to the squad for the first time since November 2022.
The 24-player squad will meet at St George's Park next week before hosting the United States at Wembley later this month and host Switzerland in the 2025 European Championship at Bramall Lane on December 3.
English selection complete
Goalkeepers: Mary Earps (PSG), Hannah Hampton (Chelsea), Anna Moorhouse (Orlando Pride).
Defenders: Lucy Bronze (Chelsea), Millie Bright (Chelsea), Jess Carter (Gotham), Alex Greenwood (Manchester City), Leah Williamson (Arsenal), Esme Morgan (Washington Spirit), Millie Turner (Manchester United), Gabby George ( Manchester United), Maya Le Tissier (Manchester United).
Midfielders: Grace Clinton (Manchester United), Fran Kirby (Brighton), Jess Park (Manchester City), Laura Blindkilde Brown (Manchester City), Georgia Stanway (Bayern Munich), Keira Walsh (Barcelona). Ruby Mace (Leicester).
Forwards: Aggie Beever-Jones (Chelsea), Chloe Kelly (Manchester City), Beth Mead (Arsenal), Alessia Russo (Arsenal), Jess Naz (Tottenham).
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