Manchester City seems to have had a defense injury after Nathan Ake had come to Plymouth in the 3-1 FA Cup victory.
Ake was replaced in the fifth round draw during the Etihad Stadium during the break, replaced by Ruben Dias.
And city boss Pep Guardiola, who has John Stones and Manuel Akanji on the sidelines, said in his press conference after the game: “Now we have central defenders again. I think we're going to miss Nathan.
'I am so grateful and grateful to the club for taking with them (January signing sessions Abdukodir) Khusanov and Vorror (travel), otherwise we would not have any chance to be eligible for the Champions League next season or fight for the FA Cup – impossible.
“We would just have Ruben.
“That's why it's a miracle that they are here to help us, because it happened all season, with the problems we had and still.”
The FA Cup is a last chance for City – who fell 20 points on drift from leaders Liverpool in the Premier League and have left the Champions League in the play – off for the last 16 – to secure silverware in their disappointing season.
They went on to the quarterfinals after they had come from behind to defeat the Plymouth championship struggle, the shock reviewers about Liverpool and Brentford in the previous two rounds.
Argyle threatened another upset when they went in front of the 38th minute head of Maksym Talovierov.
The lead lasted until the first half of the stopping time when Nico O'Reilly went home, and the 19-year-old then added another header in the 76th minute, while the pressure of the city finally told, with Kevin De Bruyne and then the hosts in the last eight sealed with a close-range finish.
Guardiola, who made 11 changes to the draw, said: 'I don't take the difficulty for granted if you play an incredibly organized team.
'It is no surprise what they did against Liverpool. It is difficult to challenge them because they have been organized incredibly defensively.
'I don't take it a matter of course how good we have done a lot of things. I feel that every step gets better. Many good things have happened. Jack (Grealisk), Vorror played really well, and all, Nico. We had a lot of possession with patience.
'I don't know how many chances or shots (we had), maybe not on goal because of the ball – the ball is difficult to bring where you want, because sometimes this type of ball does what it wants.
'But really, really happy with the performance, to be in the quarterfinals again.
'It has been a difficult year, we have not been good, the (winning the FA Cup) will not change that the season was not good. The season has not been good, but we can do well for the future.
'The mood is good, I think the team will play much better in the past month. We played really well against Liverpool and against Chelsea. Against Real Madrid (when they were beaten from the Champions League) forget it.
“But step by step I see good things. Everyone is connected and we compete for the last 11 games to be in the Champions League next season. '
Plymouth boss Miron Muslic was proud of what he had seen from his team, those second buttocks are in the championship.
“I think we can only be disappointed about the result, but very proud of the performance,” he said.
'I think we have given Manchester City a good game. It is one of the best teams in the world, coached by the best coach in this sport.
“We tried everything, we gave Manchester City a task and a big challenge, and I am very proud of this.”