The Italian club is expected to generate around € 150 million (£ 125.5 million) of the sale of Khvicha Kvaratskhelia and Victor Osimhen at the end of the season.
Napoli is planning to re -invest a part of that income to strengthen their team, with Zirkzee popping up as an important target.
The Dutch attacker was closely followed by Napoli Scouts, who regard him as a potential replacement for Osimhen.
Zirkzee's technical skills and goals score, have attracted the attention of various top European clubs, but Napoli wants to protect his signature early.
A movement could come true as soon as the transfer window is reopened, depending on the posture of United and the role of Zirkzee under Ruben Amorim.
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