Marcus Rashford will miss the rest of the season after a hamstring injury.
The 27-year-old came up the injury during the first half of the 2-1 defeat of Aston Villa against Manchester City and could have played his last game for his on-Loan club.
Rashford has scored four goals and delivered six assists since he came to Unai Emery in January.
But in the weekend he was held outside their 3-0 FA Cup semi-final loss against Crystal Palace, in which Emery predicts that he will come out 'a few weeks'.
It is not assumed that the attacker needs surgery, although further tests will be performed to determine the severity of his injury.
Aston Villa is in seventh place, only three points of the last spot of Champions League.
After they have been beaten out of the FA Cup, they only have four games this season, including a against Rashford's parent side Manchester United.
It is not impossible that he could return on time for their last fixture of the season against Spurs on May 18.
Villa's loan agreement for Rashford includes an option of £ 40 million to buy, but his future is uncertain.
Asked about the future of Rashford on Friday, Amorim said: 'All players on loan, they will return and then the club will decide what to do at the end of the season.
'Yes, of course (I am happy with their shape). The talent of Rashford, the talent of Antony, all these players, must put it in the team. So we are very happy, because if you bring a player on loan, the best for us is that they perform and perform them. '
Rashford, who came through the Academy of Manchester United, is under contract in Old Trafford until 2028.
However, it is unlikely that he will return to Old Trafford, while Ruben Amorin is in charge.
Rashford will also have a say in his next step, and it is clear that his representatives will only sit for conversations at the earliest until mid -June.
The attacker does not want to move to London and would like to become a member of a club in the Champions League.
Villa's hope for qualifying suffered a setback when she lost 2-1 with a 94th minute winner last Tuesday in Manchester City after Rashford was leveled from the penalty spot.
In the meantime, Unai Emery had hinted last week that Rashford ran for Ollie Watkins in the Aston Villa Piking order because he can play in more than one position.
The On-Loan Manchester United star was mainly signed to play as a broad attacker, but in recent competitions, Watkins had preferred the NO9-role to great frustration of the top scorer of Villa.
“You always need two strikers and being versatile is better,” said the villa boss. 'Rashford is versatile.
'I want players like these two if we try to reach the level we want.
Rashford, who made 62 international performances, returned to the team of England after more than a year after more than a year.
He started in both Word Cup qualifying winning against Albania and Latvia.
The face of England Andorra in a different qualifying match on 7 June before he organized Senegal three days later.